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ea0090p29 | Calcium and Bone | ECE2023

TransCon PTH Improves Health-Related Quality of Life and Reduces Work Limitations in Adults With Hypoparathyroidism: Patient-Reported Outcomes in the Phase 3 PaTHway Trial

Palermo Andrea , Khan Aliya , Rubin Mishaela , Schwarz Peter , Shoback Dolores M. , Gagnon Claudia , Cetani Filomena , Clarke Bart L. , Tsourdi Elena , Kohlmeier Lynn , Sikjaer Tanja , M Kaiser Stephanie , Lai Bryant , Le John , Ukena Jenny , Sibley Christopher , Shu Aimee , An Xubei , Noori Wahidullah , Smith Alden , Vokes Tamara J.

Background: Individuals with hypoparathyroidism often experience a range of symptoms associated with reduced health-related quality of life (HRQoL) and work productivity. Conventional therapy aims to alleviate hypocalcemia and acute symptoms but fails to restore normal parathyroid hormone (PTH) physiology or improve HRQoL. In the PaTHway trial, 79% of participants treated with TransCon PTH vs. 5% placebo (P<0.0001) met the primary efficacy endpoint (normal serum c...

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ea0099oc2.2 | Oral Communications 2: Calcium and Bone | Part I | ECE2024

Sustained improvement in renal function with palopegteriparatide in adults with chronic hypoparathyroidism: 2-year results from the phase 3 PaTHway trial

Schwarz Peter , Rejnmark Lars , Gosmanova Elvira , Khan Aliya , Makita Noriko , Imanishi Yasuo , Takeuchi Yasuhiro , Sprague Stuart , Shoback Dolores M. , Kohlmeier Lynn , Rubin Mishaela , Palermo Andrea , Gagnon Claudia , Tsourdi Elena , Zhao Carol , Makara Michael , Ominsky Michael , Lai Bryant , Ukena Jenny , Sibley Christopher , Shu Aimee

Hypoparathyroidism is an endocrine disease caused by insufficient levels of parathyroid hormone (PTH). Individuals with chronic hypoparathyroidism managed with conventional therapy (active vitamin D and calcium) are at increased risk for renal complications and declines in renal function. In clinical trials, palopegteriparatide treatment enabled independence from conventional therapy (no active vitamin D and ≤600 mg/day elemental calcium) and maintained serum biochemistr...

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Endocrine Abstracts

TransCon PTH Improves Health-Related Quality of Life and Reduces Work Limitations in Adults With Hypoparathyroidism: Patient-Reported Outcomes in the Phase 3 PaTHway Trial

Sustained improvement in renal function with palopegteriparatide in adults with chronic hypoparathyroidism: 2-year results from the phase 3 PaTHway trial

BiosciAbstracts